不对称小分子催化合成工艺研究

Study on Catalytic Synthesis Process of Asymmetric Small Molecules

摘要

不对称小分子催化是绿色手性合成的核心技术，具备反应条件温和、催化剂易修饰、无金属残留等相应优势，是现阶段医药、精细化工领域制备手性化合物的常用技术。明确不对称小分子催化剂设计与优化方法、完善不对称小分子催化合成反应体系是十分必要的。需要紧抓反应溶剂体系筛选、核心反应工艺参数调控、反应添加剂的辅助调控及反应体系多参数协同调控等关键要点明确技术应用路径，更好地发挥不对称小分子催化合成工艺优势，助力手性合成工艺向高效、绿色、低成本发展。

Abstract

Asymmetric small molecule catalysis serves as a core technology for green chiral synthesis, offering advantages such as mild reaction conditions, easy catalyst modification, and absence of metal residues. It has become a widely adopted technique for preparing chiral compounds in pharmaceutical and fine chemical industries. It is imperative to establish clear methodologies for designing and optimizing asymmetric small molecule catalysts, as well as to refine catalytic synthesis reaction systems. Key strategies include rigorous screening of reaction solvent systems, precise control of core process parameters, auxiliary regulation of reaction additives, and multi-parameter synergistic control of reaction systems. These approaches will enable better utilization of asymmetric small molecule catalytic synthesis advantages, facilitating the development of chiral synthesis processes toward higher efficiency, environmental sustainability, and cost-effectiveness.

关键词

不对称小分子 / 催化合成工艺 / 技术应用 / 生产质量

Key words

asymmetric small molecules / catalytic synthesis process / technological application / production quality

参考文献

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