光动力联合免疫检查点抑制剂治疗恶性肿瘤的研究进展
冯玫 , 王馨 , 李扬 , 李晓京 , 郭佳丽
山西大学学报(自然科学版) ›› 2025, Vol. 48 ›› Issue (04) : 815 -828.
光动力联合免疫检查点抑制剂治疗恶性肿瘤的研究进展
Research Progress of Photodynamic Combined Immune Checkpoint Inhibitors in the Treatment of Malignant Tumors
Malignant tumors are seriously harmful to human health. Photodynamic therapy is an emerging therapy with advantages of low trauma, low side effects and high spatiotemporal control. It has been widely used in the clinical treatment of malignant tumors, but it is limited to the treatment of local tumors. For distant metastatic tumours or lesions that cannot be precisely located, photodynamic therapy has certain limitations. Immunotherapy, especially immune checkpoint inhibitors, has brought the treatment of malignant tumors into a new era. However, the low expression level of immune checkpoint in tumor cells and its insufficient activation of the host immune system constitute major obstacles. Photodynamic therapy can activate the immune function of the body and improve the tumor microenvironment, which provides a possibility for the combination of photodynamic therapy and immunotherapy. Nanoparticles can simultaneously load photosensitizers and immune checkpoint inhibitors to achieve combined therapeutic effect and improve drug targeting. In this paper, the experimental research on the combination of photodynamic and immune checkpoint inhibitors using nanotechnology in the treatment of malignant tumors is reviewed. And its clinical application is prospected.
光动力疗法 / PD-1/PD-L1 / CTLA-4 / 联合治疗 / 纳米载药粒子
photodynamic therapy / PD-1/PD-L1 / CTLA-4 / combination therapy / nano drug-carrying particles
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