PRRSV编码蛋白在感染中的作用机制研究进展

Research Progress on the Mechanisms of Action of PRRSV- Encoded Proteins During Infection

摘要

猪繁殖与呼吸综合征（Porcine Reproductive and Respiratory Syndrome，PRRS）主要是由猪繁殖与呼吸综合征病毒（Porcine Reproductive and Respiratory Syndrome Virus，PRRSV）所引起的，该病症在母猪群体中，主要表现为流产、产出死胎、弱仔以及木乃伊胎；在仔猪群体里，则以呼吸功能出现障碍以及罹患败血症为显著特征。PRRSV有着较快的传播速度和较强的传染性，这使得PRRS在规模化养猪场中成为一种常见的接触性传染病。PRRSV的流行对养猪业造成严重的经济影响。科学防治PRRS需要对病原生物学，特别是病原感染机制的知识。因此，本文从PRRSV的基因组结构，各个病毒编码蛋白的功能、特别是病毒蛋白在感染中的作用机制等方面进行综述，旨在为PRRSV的研究以及制定相应的防控策略提供参考。

Abstract

Porcine Reproductive and Respiratory Syndrome (PRRS) is primarily caused by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The disease is characterised by abortions, stillbirths, weak litters and mummified foetuses in sows, and respiratory disorders and septicaemia in piglets. PRRSV exhibits a rapid transmission speed and high infectivity, making PRRS a common contagious disease in large-scale pig farms. The prevalence of PRRSV causes severe economic losses in the pig industry. Scientific prevention and control of PRRS requires profound knowledge of pathogen biology, especially the pathogenic infection mechanism. Therefore, this paper reviews the research progress regarding PRRSV genomic structure, the functions of virus-encoded proteins, and especially the mechanism of viral protein action during infection, aiming to provide a reference for PRRSV research and for the development of corresponding prevention and control strategies.

关键词

猪繁殖与呼吸综合征病毒 / 结构蛋白 / 非结构蛋白 / 感染机制

Key words

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) / structural protein / non-structural protein / infection mechanism

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