基于化学成分、网络药理学的参葛补肾胶囊质量标志物预测分析

Prediction and analysis of Q-Marker for Shenge Bushen Capsules based on chemical composition and network pharmacology

摘要

参葛补肾胶囊是在中医传统理论指导下,结合现代制药工艺研制而成的中药复方制剂,适用于轻、中度抑郁症中医辨证属气阴两虚、肾气不足证。本文在总结参葛补肾胶囊化学成分的基础上,应用网络药理学的研究方法并结合质量标志物(Q-Marker)的核心理论,对参葛补肾胶囊的Q-Marker进行预测分析。芒柄花素、3′-甲氧基黄豆苷元、大豆苷元4,7-二葡萄糖苷、葛根素、淫羊藿苷、脱水淫羊藿素、金圣草素、山柰酚、木犀草素、槲皮素等是参葛补肾胶囊的关键活性成分且可作为参葛补肾胶囊的Q-Marker,为参葛补肾胶囊建立全方位的质量标准提供参考依据。

Abstract

Shenge Bushen Capsule is a traditional Chinese medicine (TCM) compound preparation developed under the guidance of TCM theory and combined with modern pharmaceutical technology. It is indicated for mild to moderate depression of TCM syndrome of qi and yin deficiency, and kidney qi deficiency. Based on a summary of the chemical constituents of Shenge Bushen Capsule, this study applied network pharmacology methods and integrated the core concept of quality marker (Q-Marker) to predict and analyze the Q-Marker of Shenge Bushen Capsule. The results showed that formononetin, 3'-methoxydaidzein, daidzein-4,7-diglucoside, puerarin, icariin, anhydroicaritin, chrysoseriol, kaempferol, luteolin, and quercetin are the key active components of Shenge Bushen Capsules and can serve as its Q-Marker. Which can provide a reference for establishing a comprehensive quality standard for Shenge Bushen Capsule.

关键词

参葛补肾胶囊 / 抑郁症 / 化学成分 / 网络药理学 / 质量标志物

Key words

Shenge Bushen Capsule / depression / chemical composition / network pharmacology / Q-Marker

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基金资助

乌鲁木齐市“红山英才”计划资助项目(20251219)