基于生物信息学分析STRA6在肺腺癌中的表达及意义

Analysis of The Expression and Significance of STRA6 in Lung Adenocarcinoma Based on Bioinformatics

摘要

目的 利用生物信息学研究STRA6在肺腺癌（LUAD）中的表达及其在LUAD发生发展中的潜在作用。方法 利用TCGA、GEO、LinkedOmicsKB、Kaplan-Meier Plotter、LinkedOmics、String、TISIDB等平台检测STRA6在LUAD中的表达、预后、相关基因功能富集、免疫细胞浸润、免疫检查点,并进行分析。结果 LUAD组织中STRA6的表达高于正常组织;STRA6可能通过免疫相关通路潜在地调节LUAD的发病机制,对LUAD细胞的增殖和迁移存在影响;STRA6可能通过免疫浸润发挥其致癌作用。结论 STRA6可作为LUAD的免疫治疗靶点,可能通过激活致癌途径和调节TME来驱动LUAD癌变。

Abstract

Objective To investigate the expression of stimulated by retinoic acid 6（STRA6） in LUAD and its potential role in the occurrence and development of LUAD using bioinformatics. Methods Platforms such as TCGA, GEO, LinkedOmicsKB, Kaplan - Meier Plotter, LinkedOmics, String, and TISIDB were utilized to detect and analyze the expression, prognosis, functional enrichment of related genes, immune cell infiltration, and immune checkpoints of STRA6 in LUAD. Results The expression of STRA6 in LUAD tissues was significantly higher than that in normal tissues. STRA6 may potentially regulate the pathogenesis of LUAD through immune-related pathways, affecting the proliferation and migration of LUAD cells. Moreover, STRA6 might exert its carcinogenic effect via immune infiltration. Conclusion STRA6 can serve as an immunotherapeutic target for LUAD, potentially driving LUAD carcinogenesis by activating oncogenic pathways and regulating TME.

关键词

STRA6 / 肺腺癌 / 免疫微环境 / 生物信息学

Key words

STRA6 / lung adenocarcinoma / immune microenvironment / bioinformatics

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基金资助

内蒙古医学科学院公立医院科研联合基金科技项目（2023GLLH0206）; 包头医学院青年科技人才发展计划项目（BYJJ-DXX2022025）; 包头市卫生健康科技计划项目（wsjkkj009）