瘦素-胰岛素轴失调与胆囊胆固醇结石形成的相关因素研究进展

摘要

<正>胆结石是肝胆外科最常见的结石性疾病。我国胆结石的发病率约10%～15%，其中胆囊结石占70%～80%，在胆囊结石中约70%以上为胆固醇结石。胆囊结石是胆囊癌最强的危险因素[1]。胆囊胆固醇结石(cholesterol gallstones,CS) 成因繁多，各因素间或促或抑，相互交织。肥胖是CS的独立危险因素，瘦素和胰岛素调节失衡与肥胖高度相关。腹腔镜胆囊切除术是目前临床上公认的治疗胆囊结石的主要方法，相对于传统的开腹胆囊切除术具有创伤

关键词

瘦素-胰岛素轴 / 胆结石 / 胆囊胆固醇结石 / 影响因素

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基金资助

天津市卫健委科技人才培养项目（No.KJ20134）