壳寡糖的生物学功能及其在生物医学领域中应用的研究进展

Research progress in biological function of chitooligosaccharide and its application in biomedical field

摘要

壳寡糖（COS）作为天然多糖壳聚糖（CS）的降解产物，既保留了CS的良好生物相容性、无毒和可生物降解等特点，同时由于糖链缩短使相对分子质量降低，其水溶性和生物活性均得到提高且更容易被生物体吸收利用，近年来受到越来越多的关注。目前国内外学者对CS生物学功能的研究及其在生物医学领域中应用的报道较多，但对COS功能及其应用的研究报道较少。现结合国内外最新研究成果，对COS的主要生物学功能（抗炎、抗肿瘤、抗菌和促组织再生等）及其可能的作用机制进行总结和分析，并阐述其在生物医学领域中应用的研究进展，以期为COS的深入研究及其在生物医学领域中更广泛的应用提供理论依据和参考。

Abstract

Chitooligosaccharides （COS）， as the degradation products of the natural polysaccharide chitosan （CS）， retain the good biocompatibility， non-toxicity， and biodegradability of CS. Additionally， due to the shortened sugar chains and reduced molecular weight， their water solubility and bioactivity are improved， making them more easily absorbed and utilized by organisms. In recent years， COS has received increasing attention. While there are numerous studies on the biological functions of CS and its applications in the biomedical field， the research on the functions and applications of COS is relatively limited. This study summarizes and analyzes the main biological functions of COS （anti-inflammatory， anti-tumor， antibacterial， and tissue regeneration promotion） and their possible mechanisms. It also discusses the research progress in the applications of COS in the biomedical field， in order to provide the theoretical basis and reference for the further research and broader application of COS in biomedicine.

关键词

壳寡糖 / 壳聚糖 / 生物学功能 / 生物医学应用 / 组织再生

Key words

Chitooligosaccharide / Chitosan / Biological function / Biomedical application / Tissue regeneration

Author summay

王少如（1992-），女，山东省菏泽市人，在读博士研究生，主要从事牙周组织再生方面的研究。