环孢素滴眼液联合玻璃酸钠滴眼液治疗干眼临床效果的Meta分析

Meta-analysis of clinical effect of cyclosporine eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome

摘要

目的 研究环孢素滴眼液联合玻璃酸钠滴眼液治疗干眼的临床效果。方法 采用复合布尔逻辑检索方式，文献检索数据库包括知网、万方、PubMed、维普、Web-of-science等，检索时间为从建库至2024年4月1日。纳入文献质量评价使用Corchrane偏倚风险评估工具，Meta分析选择Revman5.3软件，对于连续性变量计算其均数差，对于二分类变量计算其相对危险度，另行5%置信区间计算。结果 纳入文献共17篇，文献质量评价均为B级，泪膜破裂时间试验组高于对照组，17项研究组间高度异质性(I²=99%，P<0.001)；去除较高偏移文献后，结果变为中等异质性(I²=34%，P<0.001)，差异均有统计学意义。结论 环孢素滴眼液联合玻璃酸钠滴眼液对干眼有较好的治疗效果。

Abstract

Objective To study the clinical effect of cyclosporine eye drops combined with sodium hyaluronate eye drops in the treatment of dry eye syndrome. Methods A comprehensive Boolean logic retrieval approach was employed, and the literature retrieval databases included CNKI, Wanfang, PubMed, VIP, Web of Science, etc. The retrieval period spanned from the inception of each database until April 1, 2024. The quality assessment of the included literature was conducted using the Cochrane Risk of Bias Assessment Tool. For the meta-analysis, RevMan 5.3 software was utilized; mean deviation (MD) were calculated for continuous variables, while relative risks (RR) were computed for dichotomous variables with separate 5% confidence intervals. Results A total of 17 RCTs were included, and the quality evaluation of all the literatures was grade B. The tear film break-up time (BUT) was higher in the experimental group than that in the control group. There was high heterogeneity among the 17 study groups (I²=99%, P<0.00001). After removing the literatures with relatively high bias, the result changed to moderate heterogeneity (I²=34%, P<0.00001), and the differences were all statistically significant. Conclusion Cyclosporine eye drops combined with sodium hyaluronate eye drops have a good therapeutic effect on dry eye syndrome.

关键词

环孢素滴 / 玻璃酸钠 / 干眼 / 治疗效果 / Meta分析

Key words

Cyclosporine / Sodium hyaluronate / Dry eye / Therapeutic effect / Meta-analysis

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