壳聚糖治疗牙周病的研究进展

Research progress on chitosan in periodontal disease treatment

摘要

壳聚糖是迄今为止发现的唯一天然存在的阳离子多糖，因具有良好的生物相容性、生物降解性、抗菌、抗炎、抗癌、组织修复活性和巨大载药能力等优点，在组织工程中逐渐受到重视。作为一种炎症破坏性疾病，牙周病发病率高且对口腔健康乃至全身健康都有重大影响。本文总结了壳聚糖在牙周治疗中的再生支架、药物递送、抗菌作用、抗炎和促进血管生成作用等，分析了目前存在的问题，指出了未来可能的发展方向，旨在为牙周病的治疗提供新思路。

Abstract

Chitosan is the only naturally occurring cationic polysaccharide and has gradually become a focus of attention in tissue engineering due to its good biocompatibility; biodegradability; antibacterial, anti-inflammatory, anticancer, and tissue repair activity; and great drug delivery capacity. Periodontal disease, as an inflammatory and destructive di-sease, has a high prevalence and significant impact on oral health and even systemic health. In this review, we summarize the role of chitosan in periodontal therapy, including its regenerative scaffolding; drug delivery; and antibacterial, anti-inflammatory, and angiogenesis-promoting effects. We then analyze current issues and point out possible future directions for its development, aiming to provide solutions to problems encountered in periodontal disease treatment.

关键词

牙周病 / 壳聚糖 / 多向支架 / 药物递送 / 抗菌

Key words

periodontal disease / chitosan / multidirectional scaffold / drug delivery / antibacterial properties

Author summay

温星悦，学士，Email：<email>[e-mail]</email>