静灵口服液治疗儿童抽动障碍临床观察

Clinical observation on the treatment for tic disorders in children by Jingling oral solution

摘要

目的 探讨静灵口服液治疗儿童暂时性抽动障碍的临床疗效。方法 选取2022年9月至2024年9月山东省妇幼保健院儿科门诊收治的抽动障碍患儿60例为研究对象, 随机分为观察组和对照组各30例。观察组给予静灵口服液治疗, 对照组给予盐酸硫必利治疗, 两组均治疗1个疗程（3个月）。根据耶鲁抽动严重程度量表 (YGTSS)及标准化中医证候积分量表对患儿进行临床疗效评估, 并对药物进行安全性评价。结果 治疗后两组总有效率比较, 差异无统计学意义（P>0.05）。两组治疗后YGTSS评分均明显低于治疗前, 差异均有统计学意义 (P<0.05)。治疗前后两组YGTSS评分比较, 差异均无统计学意义 (P>0.05)。治疗后两组中医证候积分均低于治疗前, 且观察组中医证候积分低于对照组, 差异均有统计学意义（P<0.05）。治疗后观察组患儿无明显不良反应, 对照组有轻微不良反应。结论 静灵口服液可有效改善阴虚风动证暂时性抽动障碍患儿的抽动症状与中医证候, 用药安全性良好。

Abstract

Objective To investigate the clinical efficacy of Jingling oral solution in the treatment of transient tic disorders in children. Methods A total of 60 children with tic disorders treated in the Pediatric Outpatient Department of Shandong Provincial Maternal and Child Health Care Hospital from September 2022 to September 2024 were enrolled as research subjects and randomly divided into an observation group and a control group, with 30 cases in each group. The observation group was treated with Jingling oral solution, while the control group received tiapride hydrochloride. Both groups were treated for one course of treatment (3 months). The clinical efficacy was evaluated using the Yale Global Tic Severity Scale (YGTSS) and standardized traditional Chinese medicine (TCM) syndrome scoring scale, and the safety of the medications was assessed. Results:There was no statistically significant difference in the total effective rate between the two groups after treatment (P>0.05). The YGTSS scores of both groups after treatment were significantly lower than those before treatment, with statistically significant differences (P<0.05); there was no statistically significant intergroup difference in YGTSS scores before or after treatment (P>0.05). The TCM syndrome scores of both groups decreased after treatment, and the scores of the observation group were lower than those of the control group, with statistically significant differences (P<0.05). No obvious adverse reactions were observed in the observation group after treatment, whereas mild adverse reactions occurred in the control group. Conclusion Jingling oral solution can effectively alleviate tic symptoms and TCM syndromes in children with transient tic disorders of Yin-deficiency and wind-stirring syndrome, with favorable medication safety.

关键词

暂时性抽动障碍 / 静灵口服液 / 临床观察 / 儿童

Key words

Transient tic disorders / Jingling oral solution / Clinical observation / Child

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基金资助

山东省中医药科技项目(M-2022195)