中性粒细胞脱颗粒内容物对肿瘤发生发展影响的研究进展^*

Research progress in understanding the role of neutrophil degranulation products in tumor initiation and progression

摘要

中性粒细胞是组成人体固有免疫系统的重要组成成分,参与机体抵抗病原体入侵过程。中性粒细胞脱颗粒产生多种具有生物活性的颗粒内容物,作用于肿瘤微环境,影响肿瘤细胞的发生、发展及转移。该文对中性粒细胞脱颗粒的颗粒内容物介导的肿瘤微环境对于肿瘤的多效作用作一综述,探究其在肿瘤免疫治疗中可能的应用价值。

Abstract

Neutrophils are a crucial element of the human innate immune system, contributing to the body's defense against pathogen invasion. Neutrophils undergo degranulation, releasing diverse bioactive granule contents that affect the tumor microenvironment, ultimately impacting the start, development, and metastasis of tumor cells. This article reviews the pleiotropic effects of the tumor microenvironment mediated by granule contents released during neutrophil degranulation on tumors and examines their possible applicability in tumor immunotherapy.

关键词

中性粒细胞脱颗粒 / 颗粒内容物 / 肿瘤微环境 / 免疫治疗

Key words

Neutrophil degranulation / Particle contents / Tumor microenvironment / Immunotherapy

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基金资助

^*甘肃省自然科学基金项目(22JR5RA007)