外泌体在慢性呼吸系统疾病治疗的研究进展

摘要

慢性呼吸系统疾病（chronic respiratory diseases,CRD）危害严重,病程长,现有临床治疗以对症为主,不能实现基本的修复。本文系统梳理外泌体在慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）、哮喘、肺纤维化（pulmonary fibrosis,PF）、慢性肺炎、肺动脉高压（pulmonary hypertension,PH）等主要慢性呼吸系统疾病中的基础研究与初步临床探索进展,全面归纳外泌体通过修复肺泡屏障、抑制气道重塑、减轻肺纤维化等核心机制发挥治疗作用的研究依据,重点聚焦雾化吸入这一肺部靶向给药途径的转化应用成果,同时客观分析当前仍存在分离纯化、机制解释和临床转化等困难,但未来可以通过标准化建设、相关技术改进使外泌体成为重要的治疗手段。

关键词

外泌体 / 慢性呼吸系统疾病 / 无细胞治疗

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