维生素D干预铁死亡在糖尿病及其并发症中的研究进展

Progress in research on vitamin D targeted regulation of ferroptosis in diabetes mellitus and its complications

摘要

铁死亡是一种新型的细胞死亡形式，是由铁依赖性脂质过氧化引起的调节性细胞死亡，其以脂质活性氧的累积和大量铁的沉积为主要特点，区别于细胞坏死、凋亡和自噬。糖尿病是一种以高血糖为特征的慢性代谢性疾病，其致病的特点是胰岛β细胞功能障碍而导致的胰岛素分泌不足。胰岛β细胞对氧化应激反应敏感，从而易发生铁死亡。维生素D具有抗炎及免疫调节等作用。近年来，关于维生素D调控铁死亡途径改善糖尿病的相关研究逐渐成为热点，本文将重点从维生素D干预铁死亡在糖尿病及其并发症中的相关机制作一综述，以期为糖尿病及其并发症的诊疗提供参考。

Abstract

Ferroptosis is a new form of regulatory cell death, mainly characterized by the accumulation of lipid reactive oxygen species and the deposition of large amounts of iron, which is different from cell necrosis, apoptosis and autophagy. Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia, which is characterized by insufficient insulin secretion due to insulin resistance and dysfunction of islet beta cells. Pancreatic beta cells are more sensitive to oxidative stress, and thus are susceptible to ferroptosis. Vitamin D has anti-inflammatory and immunomodulatory effects. In recent years, the research on vitamin D regulating ferroptosis pathway to improve diabetes has become a hot topic. This article focused on the mechanism of vitamin D intervention in ferroptosis in diabetes and its complications, in order to provide a reference for it.

关键词

维生素D / 铁死亡 / 糖尿病 / 糖尿病并发症 / 谷胱甘肽 / 酰基辅酶A合成酶长链家族成员4 / 核因子-红细胞2相关因子2 / 血红素加氧酶1

Key words

vitamin D / ferroptosis / diabetes mellitus / diabetic complication / reduced glutathione / long-chain acyl-coenzyme A synthase 4 / nuclear factor erythroid 2-related factor 2 / heme oxygenase 1

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基金资助

国家自然科学基金资助项目(81960160)

甘肃省自然科学基金资助项目(24JRRA1060)