光动力治疗右颊黏膜疣状癌1例报道及文献回顾

吕世萍; 杨璐; 金鑫

doi:10.12016/j.issn.2096-1456.2024.02.007

口腔疾病防治 ›› 2024, Vol. 32 ›› Issue (2) : 131 -136. DOI: 10.12016/j.issn.2096-1456.2024.02.007

防治实践

光动力治疗右颊黏膜疣状癌1例报道及文献回顾

吕世萍, 杨璐, 金鑫

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Photodynamic therapy in the treatment of the right buccal mucosa verrucous carcinoma: a case report and literature review

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摘要

目的探讨口腔疣状癌的光动力治疗方法及疗效，为临床提供参考。方法本研究遵循医学伦理学要求，对1例发生在右颊黏膜直径约2.5 cm的口腔疣状癌的光动力治疗进行总结，结合文献对口腔疣状癌的特点、治疗及口腔黏膜潜在恶性疾患的光动力治疗进行回顾性分析。结果该口腔疣状癌患者先后进行4次光动力治疗，右颊病损面积显著减小。术后随访6个月，右颊白色疣状增生完全消退，无明显瘢痕形成。术后3年，右颊病损无复发，治疗区域无明显瘢痕形成，张口度3指，双侧颌下、颏下、颈部均未触及淋巴结肿大。文献回顾表明，口腔疣状癌是一种少见的鳞状细胞癌亚型，具有生长缓慢、低度恶性、极少转移的特点，手术是首选治疗手段，但存在一定局限性。光动力治疗具有微创性、可重复操作、不良反应轻微等优势，近年来光动力治疗已逐步应用于口腔黏膜潜在恶性疾患和早期口腔鳞状细胞癌的治疗，并取得了积极结果，但尚未见用于口腔疣状癌治疗的报道。结论光动力治疗为口腔疣状癌提供了一种非手术切除的新选择。

Abstract

Objective To explore the photodynamic treatment method and therapeutic effect of oral verrucous carcinoma and to provide a reference for the clinic. Methods This study follows the requirements of medical ethics. This paper summarized the photodynamic treatment of an oral verrucous carcinoma with a diameter of approximately 2.5 cm in the right buccal mucosa and retrospectively analyzed the characteristics and treatment of oral verrucous carcinoma and the photodynamic treatment of potential malignant lesions of the oral mucosa through a review of the literature. Results After four rounds of photodynamic therapy, the size of the right buccal lesion was significantly reduced. After 6 months of follow-up, the white verrucous hyperplasia of the right buccal mucosa had completely subsided, and there was no obvious scar formation. Three years after treatment, there was no recurrence of the lesion in the right buccal mucosa and no obvious scar formation in the treated area. The degree of mouth opening was 3 fingers, and there was no lymph node enlargement in the bilateral submandibular, submental or neck. The literature review shows that oral verrucous carcinoma is a rare subtype of squamous cell carcinoma with the characteristics and biological behaviors of slow growth, low malignancy, and rare metastasis. Surgery is the preferred treatment, but there are some limitations. Photodynamic therapy is a minimally invasive, repeatable treatment with mild adverse reactions. In recent years, photodynamic therapy has been gradually applied for the treatment of potential malignant disorders of the oral mucosa and early oral squamous cell carcinoma and has achieved positive results, but it has not been reported for the treatment of oral verrucous cancer. Conclusion Photodynamic therapy is a new option for nonsurgical resection of oral verrucous carcinoma.